| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TOP2B |
(13S)-8-(2,6-dimethylpyridin-4-yl)-7-fluoro-13-methyl-4-oxo-10-oxa-1-azatricyclo[7.4.1.05,14]tetradeca-2,5,7,9(14)-tetraene-3-carboxylic acid |
NA |
NA |
NA |
150000 |
NA |
NA |
TTD |
| TOP2B |
6-(2,6-Dimethylpyridin-4-yl)-7-fluoro-2,2-dimethyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid |
NA |
NA |
NA |
510000 |
NA |
NA |
TTD |
| TOP2B |
(2S)-6-(2,6-dimethylpyridin-4-yl)-7-fluoro-2-methyl-10-oxo-1,4-diazatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid |
NA |
NA |
NA |
730000 |
NA |
NA |
TTD |
| TOP2B |
(2S)-6-(2,6-dimethylpyridin-4-yl)-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5,7,9(13),11-tetraene-11-carboxylic acid |
NA |
NA |
NA |
290000 |
NA |
NA |
TTD |
| TOP2B |
6-(2,6-Dimethylpyridin-4-yl)-7-fluoro-10-oxospiro[4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-2,1'-cyclopropane]-11-carboxylic acid |
NA |
NA |
NA |
130000 |
NA |
NA |
TTD |
| TOP2B |
[(3S,10R,13R,17R)-17-((E)-(1R,4S)-4-Ethyl-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-acetic acid |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2B |
[(3S,10R,13R,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-acetic acid |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2B |
2-[(3S,10R,13R,17R)-17-((E)-(1R,4S)-4-Ethyl-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-ethanol |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2B |
1-[(3S,10R,13R,17R)-17-((E)-(1R,4S)-4-Ethyl-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-ethane-1,2-diol |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2B |
1-[(3S,10R,13R,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-ethane-1,2-diol |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2B |
(3S,10R,13R,17R)-17-((E)-(1R,4S)-4-Ethyl-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2B |
(10S,13R,14R,17R)-17-[(2R,5R)-5,6-dihydroxy-6-methylheptan-2-yl]-4,4,10,13,14-pentamethyl-5,6,7,8,12,15,16,17-octahydrocyclopenta[a]phenanthren-3-one |
NA |
149970 |
NA |
NA |
NA |
NA |
TTD |
| TOP2B |
(10R,13R,14R,17R)-2-chloro-17-[(2R,5R)-5,6-dihydroxy-6-methylheptan-2-yl]-4,4,10,13,14-pentamethyl-5,6,7,8,12,15,16,17-octahydrocyclopenta[a]phenanthren-3-one |
NA |
106800 |
NA |
NA |
NA |
NA |
TTD |
| TOP2B |
6-(2,6-Dimethylpyridin-4-yl)-7-fluoro-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid;hydrochloride |
NA |
NA |
NA |
560000 |
NA |
NA |
TTD |
| TOP2B |
7-(2,6-Dimethylpyridin-4-yl)-6,8-difluoro-4-oxothiochromene-3-carboxylic acid;hydrochloride |
NA |
NA |
NA |
140000 |
NA |
NA |
TTD |
| TOP2B |
Ofloxacin, D- |
290000 |
NA |
NA |
NA |
NA |
NA |
BindingDB |
| TOP2B |
Norfloxacin |
225000 |
NA |
NA |
NA |
NA |
NA |
BindingDB |
| TOP2B |
Ofloxacin |
232000 |
NA |
NA |
NA |
NA |
NA |
BindingDB |
| TOP2B |
Guttiferone E |
NA |
101200 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| TOP2B |
Cholesterol |
NA |
500000 |
NA |
NA |
NA |
NA |
PubChem|TTD |