| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| TOP2B |
N-[[14-[2-(diethylamino)ethyl]-4-methoxy-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9,11,13(16)-heptaen-10-yl]methyl]formamide |
NA |
NA |
NA |
240000 |
NA |
NA |
TTD |
| TOP2B |
N-[[1-[2-(diethylamino)ethylamino]-9-oxothioxanthen-4-yl]methyl]formamide |
NA |
NA |
NA |
510000 |
NA |
NA |
TTD |
| TOP2B |
2-[2-[Hydroxy(1-phenanthren-2-ylethyl)carbamoyl]phenyl]benzoic acid |
NA |
205000 |
NA |
NA |
NA |
NA |
BindingDB |
| TOP2B |
methyl N-[[14-[2-(diethylamino)ethyl]-4-methoxy-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9,11,13(16)-heptaen-10-yl]methyl]carbamate |
NA |
NA |
NA |
220000 |
NA |
NA |
TTD |
| TOP2B |
methyl N-[[14-[2-(diethylamino)ethyl]-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,9,11,13(16)-heptaen-10-yl]methyl]carbamate |
NA |
NA |
NA |
240000 |
NA |
NA |
TTD |
| TOP2B |
(2-(Diethylamino)ethyl]-2H-[1]-benzothiopyrano[4,3,2-cd]indazole-5-methanamine |
NA |
NA |
NA |
250000 |
NA |
NA |
TTD |
| TOP2B |
N-[[14-[2-(diethylamino)ethyl]-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,9,11,13(16)-heptaen-10-yl]methyl]formamide |
NA |
NA |
NA |
260000 |
NA |
NA |
TTD |
| TOP2B |
N-[[1-[2-(diethylamino)ethylamino]-7-methoxy-9-oxothioxanthen-4-yl]methyl]methanesulfonamide |
NA |
NA |
NA |
210000 |
NA |
NA |
TTD |
| TOP2B |
N-[[2-[2-(Diethylamino)ethyl]-2H-[1]-benzothiopyrano[4,3,2-cd]indazol-5-yl]methyl]methanesulfonamide |
NA |
NA |
NA |
230000 |
NA |
NA |
TTD |
| TOP2B |
1-Cyclopropyl-6,8-difluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-3-quinolincarboxylic |
NA |
NA |
NA |
150000 |
NA |
NA |
TTD |
| TOP2B |
N,N-diethyl-2-[10-(methylaminomethyl)-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,9,11,13(16)-heptaen-14-yl]ethanamine |
NA |
NA |
NA |
220000 |
NA |
NA |
TTD |
| TOP2B |
[17-(1,5-Dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yloxy]-acetic acid |
NA |
500000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2B |
1-[2-(Diethylamino)ethylamino]-7-methoxy-4-(methylaminomethyl)thioxanthen-9-one |
NA |
NA |
NA |
500000 |
NA |
NA |
TTD |
| TOP2B |
2-[2-[hydroxy-[1-(10H-phenothiazin-2-yl)ethyl]carbamoyl]phenyl]benzoic acid |
NA |
1360000 |
NA |
NA |
NA |
NA |
BindingDB |
| TOP2B |
1-[[2-(Diethylamino)ethyl]amino]-4-[(methylamino)methyl]thioxanthen-9-one |
NA |
NA |
NA |
270000 |
NA |
NA |
TTD |
| TOP2B |
N-[(7S)-1,2-dihydroxy-3-methoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide |
NA |
150000 |
NA |
NA |
NA |
NA |
TTD |
| TOP2B |
PD-117596 |
NA |
NA |
NA |
340000 |
NA |
NA |
TTD |
| TOP2B |
4-[3-(3-Oxopiperazin-1-yl)butan-2-yl]piperazine-2,6-dione |
NA |
505000 |
NA |
NA |
NA |
NA |
BindingDB |
| TOP2B |
CID 135150944 |
NA |
200000 |
NA |
NA |
NA |
NA |
BindingDB |
| TOP2B |
1-Ethyl-6-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid |
NA |
NA |
NA |
570000 |
NA |
NA |
TTD |