| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| APEX1 |
10-(4-Methoxyphenyl)-2,4-dioxopyrimido[4,5-b]quinoline-8-carbonitrile |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| APEX1 |
10-(3-Hydroxy-4-methoxyphenyl)-2,4-dioxopyrimido[4,5-b]quinoline-8-carbonitrile |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| APEX1 |
10-(3-Fluorophenyl)-2,4-dioxopyrimido[4,5-b]quinoline-8-carbonitrile |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| APEX1 |
10-(4-Bromophenyl)-2,4-dioxopyrimido[4,5-b]quinoline-8-carbonitrile |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| APEX1 |
10-(3-Aminophenyl)-2,4-dioxopyrimido[4,5-b]quinoline-8-carbonitrile |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| APEX1 |
N-[3-(8-cyano-2,4-dioxopyrimido[4,5-b]quinolin-10-yl)phenyl]methanesulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| APEX1 |
N-[3-(2,4-dioxopyrimido[4,5-b]quinolin-10-yl)phenyl]methanesulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| APEX1 |
N-[3-(7-chloro-2,4-dioxopyrimido[4,5-b]quinolin-10-yl)phenyl]methanesulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| APEX1 |
3-(8-Cyano-2,4-dioxopyrimido[4,5-b]quinolin-10-yl)benzenesulfonamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| APEX1 |
10-(1H-indazol-6-yl)-2,4-dioxopyrimido[4,5-b]quinoline-8-carbonitrile |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| APEX1 |
10-(1H-indazol-4-yl)-2,4-dioxopyrimido[4,5-b]quinoline-8-carbonitrile |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| APEX1 |
2,4-Dioxo-10-[3-(1h-Tetrazol-5-Yl)phenyl]-2,3,4,10-Tetrahydropyrimido[4,5-B]quinoline-8-Carbonitrile |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| APEX1 |
2-[3-(8-Cyano-2,4-dioxopyrimido[4,5-b]quinolin-10-yl)phenyl]acetamide |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| APEX1 |
1-(Cyclopropylmethyl)-3-(4-ethylphenyl)-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7-dione |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| APEX1 |
8-chloro-3-methyl-10-phenylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| APEX1 |
8-chloro-10-(4-methylphenyl)pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| APEX1 |
6-chloro-10-phenylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| APEX1 |
10-benzyl-8-chloro-2-hydroxypyrimido[4,5-b]quinolin-4(10H)-one |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| APEX1 |
8-Chloro-10-phenylpyrimido[4,5-b]quinoline-2,4-dione |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |
| APEX1 |
10-phenylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |